AGI May 41/5
نویسندگان
چکیده
Buéno, Lionel, Jean Fioramonti, and Rafael GarciaVillar. Pathobiology of Visceral Pain: Molecular Mechanisms and Therapeutic Implications. III. Visceral afferent pathways: a source of new therapeutic targets for abdominal pain. Am J Physiol Gastrointest Liver Physiol 278: G670–G676, 2000.—Visceral pain is the major cause of consulting in gastroenterology and the principal symptom of functional bowel disorders. This symptom is often associated with gut hypersensitivity to distension. The use of animal models has recently permitted the identification of some mediators supposed to play a pivotal role in the genesis of visceral hypersensitivity. Serotonin, through different receptor subtypes, as well as kinins and calcitonin gene-related peptide, are known to be involved, but other putative transmitters arise and are new potential targets for the development of efficacious treatments. This themes article addresses both physiological and preclinical issues of interest for the selection of active new drugs in regard to the clinical pharmacology of visceral pain.
منابع مشابه
AGI May 41/5
NICOLA L. JONES,1,2,3 AVINASH ISLUR,1 RIZWAN HAQ,4 MARIOLA MASCARENHAS,1 MOHAMED A. KARMALI,2 MARY H. PERDUE,5 BRENT W. ZANKE,4 AND PHILIP M. SHERMAN1,2,3 1Research Institute, Hospital for Sick Children, and Departments of 2Molecular Microbiology and Medical Genetics and 3Pediatrics, University of Toronto, Toronto M5G 1X8; 4Department of Medicine, University of Toronto, Princess Margaret Hospit...
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